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The exact signaling pathway of PPAR in UF has not been clearly characterized despite the fact that PPAR protein isoforms are expressed at higher levels in UF (Tsibris et al., 1999) or a relatively equal level as compared to the normal myometrium ( Apoptosis of uterine leiomyoma cells was also stimulated by the expression of caspase-3, an important mediator for apoptosis, and by caspase-9, an initiator of apoptosis (Yu et al., 2008)

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