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Abbreviations AHI: Apnea-Hypopnea Index CV: Cardiovascular ETD: Estimated Treatment Difference HFpEF: Heart Failure with Preserved Ejection Fraction MACE: Major Adverse Cardiovascular Events MASLD: Metabolic-Associated Steatotic Liver Disease MASH: Metabolic-Associated Steatohepatitis OA: Osteoarthritis QOL: Quality of Life RRR: Relative Risk Reduction (1-Hazard Ratio) References Apovian CM

The SELECT trial enrolled a specific population - adults with pre-existing cardiovascular disease - so this finding applies directly to that population

Established Safety Profile# Recommendation : CagriSema Reason : Builds on semaglutide's 7+ year post-marketing safety record and over 25,000 clinical trial participants

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