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Patients frequently describe semaglutide as the first intervention that made behavioral change feel possible because the pharmacologic action removes the constant cognitive pull toward food that makes sustained caloric restriction so difficult without medication

The mean changes from baseline to Week 26 were -2.2 kg, -3.1 kg and -0.6 kg in the semaglutide tablets 7 mg, semaglutide tablets 14 mg and sitagliptin 100 mg arms, respectively

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