Erring on the side of caution is appropriate
In the GLP-1 RA group, 190 (1.2%) deaths occurred with a median [IQR] time-to-event of 647 [1881,407] days, whereas the DPP-4i group experienced 175 (1.1%) deaths with a median time-to-event of 549 [2301099] days
An important note for the research community: afamelanotide is the INN (International Non-proprietary Name) assigned to Melanotan 1 following clinical development
Notably, despite the dramatic difference in d 3 -TMAO production from oral d 3 -l-carnitine in omnivores versus vegans/vegetarians, the difference observed in the first step of that gut microbiotamediated transformation, conversion of d 3 -l-carnitine to d 3 -BB, was not significant, and if anything showed a trend toward a lower conversion rate in the omnivores ( P = 0.051
Pancreatitis Acute pancreatitis has been reported in patients receiving GLP-1 analogs, including semaglutide