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Krzastek SC, Farhi J, Gray M, Smith RP Impact of environmental toxin exposure on male fertility potential

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60 The metformin-induced decreased gluconeogenesis from the liver by AMPK-independent processes including dampening the activity of glucagon, blocking crucial enzymes of gluconeogenesis like fructose-1,6-bisphosphatase-1 and glycerol-3-phosphate dehydrogenase and enhancing glucose uptake by increased GLUT1 activity and IRS2 hence leading to reduction in plasma glucose levels

10.1038/nrendo.2014.44 35 DinourD.GrayN

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