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Consistent with our previous findings (20), oral gavage of systemically active doses of sitagliptin (10 mg/kg) inhibited plasma DPP-4 activity by approximately 85% when assessed 30 minutes after oral administration (Figure 1B)

Cumulative probability histograms were tested by Kolmogorov-Smirnov Test for each recording from at least 50 events

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Clinical observations suggest: Some patients report heartburn or acid regurgitation symptoms after starting tirzepatide Individuals with pre-existing reflux symptoms may experience exacerbation Symptoms appear more common during initial treatment phases and dose escalation Symptoms may correlate with larger meal sizes or lying down shortly after eating The exact frequency of reflux symptoms varies by indication, dose, and individual patient factors