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The "timing hypothesis" or "critical window" hypothesis, now supported by substantial mechanistic and clinical data, proposes that estrogen's cardiovascular protective effects are contingent on initiating therapy while vascular endothelium remains estrogen-responsive, generally within ten years of menopause onset or before age 60 [8]

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Liraglutide is a daily GLP1 receptor agonist (marketed as Saxenda for weight loss, Victoza for diabetes), while Semaglutide is a weekly GLP1 with generally greater average weight loss in trials