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Children NAC has been used safely in children and adolescents at doses of 6002400 mg per day in a number of clinical trials, 78,94,95,105 although one RCT in autistic children reported constipation (16.1%), increased appetite (16.1%), fatigue (12.9%), nervousness (12.9%) and daytime drowsiness (12.9%), which occurred significantly more commonly in the NAC than in the placebo group

In the U.S., the National Institutes of Health (NIH) receives an overall budget of 42 billion dollars

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While animal studies have suggested potential benefits, human safety and efficacy data are limited