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More serious but rare risks can include pancreatitis, gallbladder issues, and thyroid C-cell tumors (in animal studies)

SPRED1 facilitates the localization of NF1 to the plasma membrane where it suppresses RAS signaling ( SPRED1 inactivating mutations and 12% undergo SPRED1 copy number loss ( SPRED1 alterations are insignificant in CM (79)