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The activation of mTORC1 by leucine occurs through sensing mechanisms including Sestrin2 and leucyl-tRNA synthetase, which facilitate the phosphorylation of downstream effectors such as p70 S6 kinase 1 and 4E-BP1, thereby initiating translation and augmenting myofibrillar protein synthesis

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Checking your body weight daily can also reveal patterns: a drop of more than 23 pounds in a single day may signal fluid loss rather than fat loss, prompting you to increase water intake and reduce sodium consumption temporarily

An optimal range is typically considered to be 7-9 mol/L