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Compared with women without sickle cell disease, the review reports markedly higher risks: 6.0-times higher maternal mortality (95% CI 1.9 to 18.4) 2.4-times higher pre-eclampsia (95% CI 1.8 to 3.4) 3.9-times higher stillbirth (95% CI 2.6 to 6.0) 2.2-times higher preterm delivery (95% CI 1.5 to 3.3) 3.7-times higher small-for-gestational-age infants (95% CI 2.3 to 6.0) Much of this seems to come down to impaired placental blood flow and features of placental insufficiency

Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome

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10.1100/2012/657808 4 AnjumN