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While individually they have relatively benign safety profiles (when used appropriately), the interaction between them has not been thoroughly investigated in clinical settings

Malaguarnera M, Pistone G, Elvira R, Leotta C, Scarpello L, Liborio R: Effects of L-carnitine in patients with hepatic encephalopathy

However, volunteers 1, 3, and 4 displayed more prominent changes in butyrates and acylcarnitines than in BCAAs, while volunteer 2 showed greater increases in BCAAs than in acylcarnitines