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The translocation barrier height, G , is calculated by averaging and subtracting the value of the two lowest free energy minima ( G A and G C in Fig

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The report acknowledges that safe and effective treatment for non-relapsing SPMS remains a significant unmet health care need, as there is no FDA-approved agent for the condition

With the global prevalence of those metabolic diseases steadily rising, it is clear this class of drugs has immense potential to address the needs of large patient populations, and we are seeing a surge in development efforts among pharmaceutical players in the space

Future randomized, prospective studies are warranted to confirm these findings and optimize treatment strategies