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This is evidenced by the negligible affinity of amylin or pramlintide for the isolated CTR ECD 19,20 , and by loss of affinity and/or potency of P32Y substituted CT peptides at the CTR 18,20

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Our studies with the Broad Institute's Connectivity Map revealed its ability to regulate a large number of human genes including those that are involved in nervous system physiology, development, and maintenance

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