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Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation
Physical activity stimulates intestinal muscle contractions and accelerates stool movement
Recent scientific studies have found that patients taking semaglutide significantly more likely to develop NAION than non-users a risk that the drug manufacturers did not adequately disclose
Avoiding high-fat, greasy, or heavily processed foods is critical, as these are difficult for a slowed stomach to digest