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The peptide is not damaged, only the concentration changed

Moreover, the DPP-4-generated metabolites of GLP-1 (Figure 1), lacking the His-Ala dipeptide, have 100-fold less affinity towards GLP-1R

( 10.1016/j.mam.2004.06.006) [DOI] [PubMed] [Google Scholar] Steiner AZ, Hansen KR, Barnhart KT, Cedars MI, Legro RS, Diamond MP, Krawetz SA, Usadi R, Baker VL, Coward RMet al

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Abstract This review explores the critical function of the evolutionarily conserved ChaC-like enzyme family as central regulators of intracellular glutathione (GSH) homeostasis, focusing on the mammalian isoforms CHAC1 and CHAC2