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5 PubMed (animal studies)Selank effects on serotonin/monoamine metabolism and BDNF expression in rodents (preclinical mechanism data)

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Among those, the tyrosine derivative 28 exhibited a Ki value of 4.1 nM and the corresponding analogue with a saturated double bond, compound 29 , a Ki value of 25 nM, demonstrating that a proper constrain of flexibility of the ring system, alternatively an electron density in the center of the lipophilic bridge between amino acid residues in positions 1 and 3 is favorable for affinity to IRAP (Figure 7)

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Cancer associated fibroblasts (CAFs) in tumor microenvironment