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[1] [6] Severe deficiencies may include symptoms of reduced heart function, suppression of bone marrow, as well as more various severe neurological symptoms possibly including sensory loss, abnormal balance and reflexes, memory and consciousness impairment, smell and taste problems, depression, irritability, confusion, and psychosis

When neuroanatomical associations of this behavioral effect were analyzed, intra-NTS Ex-4 (0.05 g per side) decreased alcohol-induced locomotor behavior, accumbal dopamine release, and memory consolidation of alcohol reward in mice, whereas a lower dose (0.025 g per side) was ineffective