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Keywords: GLP-1 receptor agonists, neuroprotection, neuroinflammation, Alzheimers disease, Parkinsons disease Introduction Neurological disorders are a leading cause of death and disability worldwide and place a huge burden on patients, families, and healthcare systems

The relationship between these peptides illustrates the drug development process: MT-2 was the discovery compound, PT-141 was the optimized derivative, and only PT-141 completed the journey to approval

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This precision approach transforms GLP-1 therapy from a standardized, one-size-fits-all pharmaceutical model into a personalized medical intervention

2022;142:1349-59.e8