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Environmental Determinants of Islet Autoimmunity (ENDIA): a pregnancy to early life cohort study in children at-risk of type 1 diabetes

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Consistent with the observation that glucagon acts on the pancreatic -cells to stimulate insulin secretion via the GLP-1 receptor (GLP-1R) [24,25,26,27], long-term treatment of diet-induced obese (DIO) mice with a biochemically modified water-soluble glucagon improved glucose metabolism with equal efficacy relative to treatment with exendin-4 [23]

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