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In our study, several studies found that improvements in inflammatory markers were accompanied by decreases in albuminuria (6, 15, 17, 18)
Occupancy stays low, but each engaged receptor keeps sending its main message longer than it would under a balanced signal (cAMP bias with low receptor internalization). In a head-to-head trial against liraglutide, tirzepatide reduced measured food intake and craving more despite lower GLP-1 occupancy. The effect lowers the drive to eat rather than increasing restraint
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The core assumptions I want to stress-test in this thesis are the following: Lilly has the better molecule and is out-executing Novo
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