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Their versatility raises important questions about how these treatments are reshaping patient behaviors and treatment practices

(1) This may upregulate growth hormone (GH) synthesis, which is a hormone with catabolic potential towards fat cells, and also may possess anabolic potential via a mediator called insulin-like growth factor 1 (IGF-1) The research suggests that it may produce rapid, concentration-dependent, pulsatile GH elevations, yielding GH pulses roughly 20- to 30-fold above basal values and potentially close to other GHSs such as GHRP-6 and GHRP-2

These resolve without intervention

doi:10.1001/jamanetworkopen.2024.2822209 (Note: Publisher firewall limits full author extraction, but this is the primary citation path)