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Selective and membrane-permeable small-molecule inhibitors of NNMT reverse high-fat-diet-induced obesity in mice and remodel adipocyte metabolism (open-access)

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When the upregulating MMP-9 cannot be offset by TIMP-1 abundantly, the degradation of elastin and other extracellular matrix components occurs in the alveolar walls and finally leading to emphysema (Pardo and Selman, 1999

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