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Human data is still very limited, including small pilot work such as the knee pain survey of 16 patients, plus a few other early studies and reviews calling out the lack of large, rigorous trials

Medications such as orlistat (a pancreatic lipase inhibitor) carry FDA approval for ages 12 and up and represent a lower-risk starting point

Measure protein intake against a 1.6g/kg bodyweight minimum before attributing fatigue to glutathione depletion

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