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9598 Mechanistically, in the absence of impaired kidney function, more than 95% of TMAO in the human body is excreted through renal tubules or glomerular filtration, 99,100 suggesting a potential mechanism for elevated circulating TMAO levels when renal function is impaired

This represents the sweet spot where therapeutic effects strengthen without side effects becoming prohibitive

For weight management, inadequate response (less than 5% weight loss after several months at maintenance dose) may warrant reassessment of the treatment approach

What is surprising is the reduction in the risk of heart attacks

Weeks 3-4: A subtle lit from within glow usually begins to appear