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Taking oral semaglutide on an empty stomach helps ensure consistent and reliable absorption

[7] However, FDA labeling for both semaglutide and tirzepatide includes warnings about acute kidney injury, particularly in patients experiencing severe gastrointestinal adverse effects

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The most common side effects are mild nausea (usually temporary as your body adjusts), reduced appetite (this is actually the goal!), occasional digestive changes, and fatigue in some patients initially

Shmerling, MD Senior Faculty Editor, Harvard Health Publishing