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142 Activity-dependent mRNA translation and protein synthesis Several activity-regulated translational control pathways have been demonstrated to participate in pathologies of autism, such as the ERK/MAPK (mitogen-activated protein kinase) 143 and PI3K/mTOR (mammalian target of rapamycin) pathways

Diabetes mellitus Diabetes mellitus is a chronic metabolic disorder that is characterized by elevated blood glucose caused by deficiency or resistance to insulin

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Men with significant liver impairment should use caution because copper is metabolized hepatically

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