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PT-141 (Bremelanotide) is a man-made, laboratory analogue of alpha-Melanocyte-stimulating hormone (-MSH) that acts as a melanocortin receptor agonist with activity at MC1R, MC3R, and MC4R, and has been shown to influence pathways associated with sexual desire and arousal in the central nervous system

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NCT04847557) seeks to evaluate the effect of tirzepatide (is a dual agonist for the glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors) over 52 weeks in 700 patients with heart failure with preserved ejection fraction (HFpEF) and obesity