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The gut senses food and produces the incretins GLP-1 and GIP to tell the pancreas to get ready to take care of the calorie hit thats on its way

The opposing functions of Th17 and Treg cells maintain immune stability, whereas an imbalance can result in persistent inflammation and autoimmune disorders (60)

The current clinical treatment faces three major problems

We highlight how single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics have unveiled unprecedented cellular heterogeneity, delineated pathogenic trajectories like maladaptive tubular cell states, and established immune dysregulation as central to disease progression