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MPTP is an alipophilic prototoxin that rapidly crosses the blood-brain barrier and damage dopaminergic neurons due to the selective uptake of the active metabolite MPP + via the dopamine transporter [80]

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The hypothalamic-pituitary-gonadal (HPG) axis is suppressed by excess adiposity, elevated estrogen, insulin resistance, and chronic inflammation all of which improve when body fat decreases