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Conversely, the release of cellular components or inflammatory signals following ferroptotic cell death can amplify immune responses, establishing a self-perpetuating immunometabolic crosstalk that may accelerate lesion progression and exacerbate tissue damage in OA

Amerik A, Petukhova GV, Grigorenko VG, Lykov IP, Yarovoi SV, Lipkin VM, et al

628 Epidemiological and animal studies have shown that the imbalance of metal ion homeostasis can cause disturbance in emotional regulation

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Others experiments are needed to clarify the mechanisms of this CoQ10