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Diagnostic criteria used in AD and MCI AD patients were identified primarily using the Diagnostic and Statistical Manual of Mental Disorders (DSM) [63] and/or the National Institute of Neurological and Communicative Diseases and Stroke/Alzheimers Disease and Related Disorders Association [64]

This study has several limitations that should be acknowledged

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Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer's disease

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