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Moreover, it has been suggested that starvation reduces liver glycogen storage and hence reduces UGT conjugative ability leading to a greater fraction of the dose being oxidised to NAPQI [77]

This includes substances that improve mitochondrial function by inhibiting oxidative stress or stabilizing mitochondrial membranes

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On the other hand, cell death exposes the basement membrane, to which crystals bind directly and on which regenerating epithelium grows, pushing the crystals into the interstitium and promoting crystal retention

Also referenced as SLU-PP-332 , it is frequently used in laboratory models examining nuclear receptor signaling models and cellular response mechanisms