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Semaglutide has a reported half-life of roughly one week

What side effects and safety concerns come with GLP-1 medications, and how are they managed

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Reports are anecdotal and vary widely, including altered emotional eating patterns, mood flatness, or changes in social behaviour

Major Adverse CV Event (CV Death, Nonfatal MI, or Nonfatal Stroke) At the data cut-off date, the percentages of patients (in the FAS) with their first EAC-confirmed MACE (consisting of CV death, nonfatal MI, or nonfatal stroke) were 6.5% of 8,803 patients in the semaglutide 2.4 mg group and 8.0% of 8,801 patients in the placebo group