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Reduced food intake often means reduced water intake from food

Searches for Mounjaro and Zepbound skyrocketed between 2024 and 2025, with over 1.5 million Brits now taking a weight-loss drug (a share that has nearly doubled in this period)

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Saxenda Dosing Saxenda requires daily subcutaneous injection: Titration schedule: Administration: Inject once daily at any time Consistent timing recommended Abdomen, thigh, or upper arm injection sites Rotate sites to prevent irritation Practical burden: 365 injections per year Must remember daily More needle/supply use Higher chance of missed doses Semaglutide Dosing Semaglutide requires weekly subcutaneous injection: Titration schedule (Wegovy doses): Administration: Inject once weekly on the same day each week Any time of day Same injection sites as Saxenda Rotate sites Practical burden: 52 injections per year Weekly reminder easier than daily Less needle/supply use Better adherence typically Dosing Comparison Impact on Adherence Research consistently shows better adherence with weekly versus daily medications: Daily dosing challenges: Easier to forget More disruption to routines Higher cumulative burden Greater chance of inconsistent dosing Weekly dosing advantages: Easier to remember one day Less intrusion on daily life Can establish reliable routine Fewer opportunities to miss doses Better adherence translates to better real-world results

In rats, CCK decreased hepatic glucose production to maintain glucose homeostasis by inhibiting CCK-A receptors and triggering a gutbrainliver neuronal axis (106)