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Carvas AO, Leuthardt A, Kulka P, Lommi G, Hassan S, Coester B, et al

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In addition, GLPs suppress both the upregulated expression of the (pro)renin receptor (PRR) and its cleaved soluble variant (sPRR), leading to diminished urinary renin activity and reduced angiotensin II (Ang II) concentrationsultimately preventing pathological overactivation of the renin-angiotensin system (RAS)