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FIGURE 3 3.1.1 Curcumins epigenetic modulation: DNA methylation and wnt/ -catenin pathway regulation Curcumin exerts profound epigenetic regulatory effects in cancer by modulating DNA methylation and interfering with the Wnt/ -catenin signaling pathway, two mechanisms central to tumorigenesis and cell fate determination

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Further, given the trial continued to its final analysis without stopping for efficacy, the concern for treatment effect inflation due to early termination does not apply