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Contrary to common knowledge, patients in the subgroup with a higher BMI did not show significant weight gain (WMD = 1.21 kg, 95% CI 1.24 to 3.60, P = 0.33, I 2 = 72%) and there were no significant differences between the subgroups ( P = 0.73) (Additional file 2: Fig

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[2] The concentration differences between pens mean that visual inspection alone cannot determine the dose