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Besides, cell penetrating peptides seem promising to increase skin permeation of GHK and its derivatives

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Extracellular matrix remodeling

For instance, VitCs capacity of pH-dependent auto-oxidation and the presence of catalytic metals, such as iron and copper, usually common in cell culture media, can simultaneously increase H 2 O 2 production and impair reproducibility in vitro [206,207,208]

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