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(2023, June 28)

Mechanisms: KPV modulates inflammatory cytokines including TNF-alpha and interleukins

In animal models, the elevated TMAO levels were significantly related to tubulointerstitial fibrosis and collagen deposition in the kidney and TMAO was demonstrated to increase in kidney injury molecule-1, phosphorylation of Smad3 (Tang et al., 2015b)