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Ferrannini E (2017) Sodium-glucose co-transporters and their inhibition: clinical physiology

The gluconeogenic nature of glucagon receptor agonism is considered valuable for defending against insulin-induced hypoglycemia, and also illustrates pharmacological antagonism as a means to limit glucagon-driven fasted and post-prandial hyperglycemia [119], [148], [190], [31], [97], [98]

The evidence supports a working hypothesis worth taking seriously: paying attention matters

Front Endocrinol 10:376

Of interest, we also observed a 6-fold increase in eNOS phosphorylation in Western blotting of isolated hearts perfused with GLP-1(2836) as compared with scramble-treated controls (Supplemental Figure 7)