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Toxicological findings consistently indicate size- and shape-dependent uptake and effects: smaller particles exhibit greater cellular internalisation, reactivity, and biodistribution, with predominant oxidative, inflammatory, metabolic, and genotoxic responses, whereas larger microplastics more often provoke mechanical irritation

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Differences were analyzed using Student's t-test or one-way analysis of variance, followed by Tukey's post hoc test

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The rhythmicity of melatonin secretion is not very pronounced in young babies, but it becomes more rhythmic over time, and factors such as artificial lighting and lack of sunlight exposure can disrupt this rhythmicity, making people somewhat arrhythmic or phase-shifted 2m6s