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The combination of GPX4 inhibitors with immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis increases the proportion of CD8 + T cells, enhances their cytotoxic activity and induces ferroptosis, thereby promoting chemotherapy resistance [42]

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We show that PDS5B binds dsDNA preferentially over ssDNA and that it enhances RAD51-mediated DNA strand exchange via the capture of dsDNA

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