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doi: 10.1016/j.bbabio.2015.05.021 212 RussellJKJonesCKNewhousePA

The starting dose is typically 25 units (1.5mg) twice weekly

The majority of data derives from animal studies

The addition broadens KLOW's mechanism coverage to four pathways vs GLOW's three

Concurrently, it is imperative to disentangle the concrete regulation on functional subgroups of the gut microbiota induced by metabolites from articular ferroptosis (for example, ROS and LPO) (such as probiotic genus composition, abundance of populations such as those of Lactobacillus and the Bacteroidetes/ Firmicutes ratio) and gut structural mucosal barrier integrity (for example, the expression of tight junction proteins, such as occludin and claudin)