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Transl Psychiatry 8, 242 (2018)

Interferon regulatory factor 9 protects against cardiac hypertrophy by targeting myocardin

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NNMT upregulation was documented to elevate homocysteine levels, activating pro-inflammatory and pro-oxidative cascades including TLR4-NF-B and STAT3-IL-1 signalling

Laboratory protocols should include appropriate controls and monitoring strategies to distinguish between beneficial elimination of harmful senescent cells and potential adverse effects on beneficial senescent cell populations