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Hoeger KM, Dokras A, Piltonen T

Since DFO is membrane impermeable and accumulates in lysosomes 18 , we believe that it protects the cells against ferroptosis by chelating lysosomal iron as described previously 47

This leads to an interesting hypothesis, i.e., early in infection, the coatomer sequesters the S protein near ERGIC to provide a window for the assembly of infectious progeny virions, prior to S export to PM at a later stage for cell-cell fusion and virion transmission

Q4: Could NAD+ supplement side effects include creating a metabolic dependency?: Not in a biological sense

Glutathione deficiency leads to an increase in oxidative stress, accumulation of toxins and heavy metals