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GSTs, primarily GSTA1-1, are involved in the first step of the metabolic pathway of busulfan 79,80

Philos Trans R Soc Lond B Biol Sci

doi: 10.1080/1071576021000016463

Landmark trial programs include STEP (semaglutide for weight management, The New England Journal of Medicine , 2021), SURMOUNT (tirzepatide for weight management, NEJM 2022), and SURMOUNT-OSA (tirzepatide for obstructive sleep apnea, NEJM 2024)

These structural rearrangements reduce the distance between the two intracellular kinase domains, and thus promote trans-autophosphorylation and activation