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Who can get it: Ozempic and Rybelsus require a diagnosis of type 2 diabetes (although Ozempic can be prescribed off-label for weight loss), while Wegovy requires either a BMI of 30 or a BMI of at least 27 plus another weight-related ailment (like high blood pressure or obstructive sleep apnea)

Indeed central GLP-1 production appears essential, since peripheral GLP-1 is assumed to not be able to cross the blood-brain barrier (BBB)

Side effects: what to expect (and what to watch for) Nausea Vomiting Diarrhea Constipation Stomach pain or bloating Reflux in some people Side effects are often dose and food-related Slower dose escalation can help Red flags are not the same as common nausea Who is oral GLP-1 best for

In line with FDA guidance that clinicians monitor for new or worsening depression, suicidal thoughts, or unusual changes in mood during GLP-1 RA treatment [46], brief psychological screening should be incorporated at baseline and repeated at intervals during treatment at weeks 6, 12, and 24, and then at least every six months

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