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After 28 days, discard the vial and prepare a fresh reconstitution from lyophilized stock

The primary outcome was a composite of new-onset osteoporosis or fragility fractures within 14 months of treatment initiation

If GI side effects are severe or persistent, your healthcare provider may recommend slowing or pausing dose escalation, or in some cases, reducing the dose temporarily

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That Novo Nordisk-funded study of almost 2,000 overweight or obese adults without diabetes also found their visceral fat the type that accumulates in the belly was reduced from baseline with semaglutide, along with their total fat mass