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The membrane-bound folate receptor has the highest affinity for folate (Kd 0.11 nmol/l), characteristically binds folic acid, reduced folates, many antifolate drugs, and folate conjugates, and transports them by a non-classical endocytic mechanism 881,885

Compounded weekly injections or daily oral tablets

Benefits: Non-invasive and potential for CNS-targeted delivery

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Propionyl-L-carnitine improves exercise performance and functional status in patients with claudication